AN ANTIVIRAL SUBSTANCE FROM PENICILLIUM FUNICULOSUM
نویسندگان
چکیده
منابع مشابه
An Antiviral Substance from Penicillium Funiculosum
1. Helenine prevents the establishment in mice of passive viral immunity by anti-Semliki serum of swine, rabbit, or guinea pig origin. 2. A period of 12 days must elapse, between the antiviral serum administration and challenge with virus, for prevention of the establishment of passive immunity to become apparent. This period is believed to correspond to that in which injected antibody persists...
متن کاملThe Presence in Penicillium Funiculosum of an Inhibitor to the Antiviral Agent Helenine
The present findings indicate that the wide fluctuation observed in the antiviral activity of various crude helenine preparations may be attributable to the presence of varying amounts of inhibitor. Antiviral activity could be enhanced by removal of the inhibitor. A meaningful value for helenine titer in a preparation clearly should be determined in the inhibitor-free zone.
متن کاملGH10 xylanase D from Penicillium funiculosum: biochemical studies and xylooligosaccharide production
BACKGROUND The filamentous fungus Penicillium funiculosum produces a range of glycoside hydrolases (GH). The XynD gene, encoding the sole P. funiculosum GH10 xylanase described so far, was cloned into the pPICZαA vector and expressed in methylotrophe yeast Pichia pastoris, in order to compare the results obtained with the P. funiculosum GH11 xylanases data. RESULTS High level expression of re...
متن کاملProperties of selected hemicellulases of a multi-enzymatic system from Penicillium funiculosum.
A multi-enzymatic system from Penicillium funiculosum displayed alpha-L-arabinofuranosidase, endo-1,4-beta-D-xylanase, beta-D-xylosidase and endo-1,3-1,4-beta-D-glucanase activities at high levels over a wide acidic pH range of 2.0 to 5.5. Moreover, the pH stability was particularly extended over the wide range of pH of 2.0 to 8.0 with endo-1,3-1,4-beta-D-glucanase and endo-1,4-beta-D-xylanase;...
متن کاملInducers of interferon and host resistance. I. Double-stranded RNA from extracts of Penicillium funiculosum.
Since interferon' per se shows little promise as a prophylactic or therapeutic agent, interest has shifted to a search for acceptable inducers by which the body might be stimulated to make its own interferon. Shope2 demonstrated that a substance which was derived from Penicilliumfuniculosum and which was called helenine induced resistance to Semliki Forest and to Columbia SK virus infections in...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1953
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.97.5.601